PingResponder is a small, simple, easy to use software that allows you to ping a machine on your network or outside it at regular intervals.
If the remote machine is not responding (or more), you notify PingResponder visually and also if you wish by sending an e-mail.
NOTE: PingResponder can only be purchased via the Mac App Store (the buy link redirects you to its App Store page). To purchase/download applications via the App Store an Apple account is required.